Yes, Safepots filters support regular expressions, but you should enable the option for the regular expressions by doing the following:

• Right-click on the Safepots icon in the system tray, and select the Open Dashboard option.

• From Safepots dashboard, click on Data Selection.
• Click on File Filters.
• Click the Add button to add new filter, or click the Edit button to edit one of the existing filters.
• Check the Regular Expression box beside the option of including or excluding file types or expressions, and type the wanted regular expression.
• Save your changes.

You can find examples on how to use Regular expressions in  this article.